After Phish plays Chicago’s Wrigley Field on Saturday, June 25th, Pink Talking Fish will continue sharin’ in the (Weekapaug) groove just a 10-minute walk down the road at the Vic Theatre. The phenomenon that is PTF has taken its hold on the jam scene, with the bands unique take on seamlessly weaving in and out of Pink Floyd, Talking Heads, and Phish songs (purchase tickets HERE).With Phish playing their second baseball stadium of historical significance, Pink Talking Fish founder/bassist Eric Gould discussed his excitement to join in the revelry surrounding these shows, “Phish performing at Wrigley is something very special. I attended their show at Fenway Park (back in 2009) and it was way beyond your typical venue for music. Wrigley and Fenway are the last two classic parks of their kind in America and there is a unique energy involved. That energy carries off into the night with the people beyond the event and we are honored to offer an outlet for that excitement to continue.”This also marks the second time that PTF will be performing in The Windy City, after elites of the jam scene perform. Last summer, the band took part in the massive celebration that was the Grateful Dead’s 50th Anniversary Fare Thee Well performances at Soldier Field with three sold-out shows at Reggie’s. Gould went on to say, “Chicago became a city of music lovers last year for Fare Thee Well. PTF built our own slice of fun in the middle of it and it was an amazing time for the musicians and the audience who joined in the adventure. Coming back to Chicago for this incredible event that is Phish playing Wrigley Field feels like a homecoming from last year’s chapter in our story.”‘Pink Talking Fish Are Dead’ Concept Proves To Be An Absolute Hit In ChicagoGould, along with Richard James on keyboards, Zack Burwick on drums and Dave Brunyak on guitar, have also incorporated tributes to recently passed icons David Bowie and Prince into their setlists, making for some memorable performances (listen to full audio from one of the performances HERE). The group is constantly pushing the boundaries of where they can take the music of all these legendary artists, and doing so with style and grace. The Vic Theatre performance is sure to be a continuation of the party that will be experienced at Wrigley. You can purchase tickets for Pink Talking Fish’s post-Phish Wrigley show at the Vic Theatre HERE, and find the whole venue’s calendar HERE. You can also enter the contest below for a chance to win a pair of tickets!
Harvard Stem Cell Institute (HSCI) researchers have identified a faulty signaling pathway that, when corrected in mice, ameliorates the symptoms of Rett syndrome, a devastating neurological condition. The findings could lead to the discovery of compounds or drugs that may benefit children affected by the disease, says neurobiologist Jeffrey Macklis, a member of the HSCI Executive Committee.The research was published recently in Nature Communications. Noriyuki Kishi and Jessica MacDonald, both recent postdoctoral fellows in the Macklis laboratory, are co-first authors. Macklis, who directed the work, is the Max and Anne Wien Professor of Life Sciences in the Department of Stem Cell and Regenerative Biology, and Center for Brain Science at Harvard University.Rett syndrome is a relatively common neurodevelopmental disorder, the second most common cause of intellectual disability in girls after Down syndrome; it is associated with a dysfunctional gene on the X chromosome. Boys with Rett syndrome are rare, because male fetuses who carry the mutations on their one X chromosome usually have prenatally lethal forms of the disease.Girls with Rett syndrome appear to develop relatively normally for the first six to 18 months of life, but then regress; they tend to lose their ability to speak and the purposeful use of their hands, withdraw from social situations, and wring their hands.Austrian physician Andreas Rett first described the disorder in 1966, but it wasn’t until 1999 that Huda Zoghbi and her lab at Baylor College of Medicine identified mutations in the gene MECP2 as the root cause of Rett syndrome. MECP2, however, turns a very large number of genes on and off throughout the entire body, so it has been a long-standing puzzle why children with Rett syndrome have this very specific and reproducible developmental cognitive brain disorder.“My view was that MECP2 mutation in Rett syndrome disrupts so many genes and their protein products that we weren’t going to find a single gene that we could fix to help girls with Rett,” said Macklis, former program head of HSCI’s Nervous System Diseases Program, and an Allen Distinguished Investigator of the Paul G. Allen Family Foundation. “But if we found a disrupted, improperly regulated signaling pathway that was ‘drug-able,’ that affected enough of the girls’ pathology, we might be able to make them dramatically functionally better with already available therapeutics — and that might make a real difference in their lives and their families’ lives.”Instead of concentrating on the MECP2 gene, Macklis’ group focused on neurons he knew were “abnormal and implicated in Rett syndrome and autism spectrum disorders,” and in 2004, his lab was the first to describe abnormal development in this type of neuron. These neurons, called inter-hemispheric callosal projection neurons (CPNs), have shorter, less-developed dendrites, or “receiving antennas,” in mice with the Rett gene mutations and in individuals with Rett syndrome.Building on their 2004 findings, the researchers were able to fluorescently label CPNs in mice with or without the Rett mutation, purify them from other types of neurons, and look at the levels at which many thousands of genes were active, and thus how much of the proteins coded for by those those genes was made.They found that one gene for IRAK1, which Macklis’ group identified as regulated by MECP2 and which is a well-known part of the NF-kB signaling pathway, was making about three times more protein than normal. They modified IRAK1 levels both in mice with Rett mutations and in mouse neurons in culture dishes. When they reduced the activity of its gene Irak1 by roughly half, and consequently the amount of IRAK1 protein made, the neurons and their dendrites developed substantially better, indistinguishable from normal by several assays. Further, mice with reduced levels of IRAK1 had significantly fewer symptoms, better function, and much longer lifespan. They had much-improved health, well beyond only these neurons.Now, Macklis said, the researchers have started looking into potential compounds and drugs that are already available and that might partially correct this pathway, and what dosages and timing might ultimately ameliorate the effects of Rett syndrome.
Sign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York A New York State lawmaker suggested that he might have voted differently on a bill if he knew that the family of former state Senate Majority Leader Dean Skelos (R-Rockville Centre) allegedly profited from legislation Skelos helped pass.The lawmaker, state Sen. Tony Avella (D-Queens), made the remarks as one of four witnesses to take the stand Wednesday in the second day of the corruption trial against Skelos and his son, Adam, at federal court in Manhattan, where testimony was peppered with spicy recordings of wiretapped phone conversations of the senator talking to his son and others.“It would have indicated that undue influence was given to an issue of legislation based on personal interest,” Avella testified, adding that he also would have aired such information publicly on the Senate floor and to the press as well as called for an investigation. Defense attorneys objected to this line of questioning because it required Avella to give his opinion on allegations that prosecutors are still trying to prove in court, but U.S. District Court Judge Kimba Wood allowed it.Both the senator, 67, and his son, 33, deny the federal prosecutor’s accusations that they extorted $300,000 in bribes from three companies in payments that took the form of “no-show” jobs that Adam was unqualified for in exchange for their illegally manipulating legislation.G. Robert Gage Jr., the senator’s defense attorney, and Christopher Conniff, who represents Adam, sought to poke holes in Avella’s credibility.Gage noted that Avella, a public critic of the real estate industry, accepted campaign donations from realty groups and developers. Gage noted that when reporters questioned Avella about the contradiction, the Queens politician was quoted as saying that “the contributions have absolutely no impact on legislation.” In court, Avella, the former state Senate ethics committee chair, told Gage: “When it comes to me, they don’t.”Avella was the third witness to take the stand. The first was Chris Curcio, a Floral Park resident and Adam’s former boss at Physicians Reciprocal Insurance (PRI), a medical malpractice insurance firm whose owner had been asked by Sen. Skelos to give Adam a $78,000-per-year job as a favor beginning in 2013. Curcio testified that shortly after he met Adam, he started keeping a handwritten log for the first four months of Adam’s employment to detail when Adam did and did not show up. The majority of the dates were marked “no show,” yet Adam submitted time sheets indicating that he consistently worked 35-hour weeks.When Curcio questioned Adam about his failure to show up for work, Curcio testified that Adam told him that there was a “special arrangement” between his senator dad and Anthony Bonomo, a longtime friend of the Skeloses, which allowed him to work only two days a week. Curcio also testified that in order to sell medical malpractice insurance, Adam was required to take a 99-hour class and a state licensing exam. Curcio testified that Adam completed the class but failed the exam at least twice, and never got his license.“Adam and I had a blow-out on the phone one day,” Curcio testified, referring to his repeated attempts to force him to show up to work. Curcio said that after he told Adam it wasn’t working out, Adam told him: “If you talk to me like that again, I’ll smash your fucking head in.”Read: Skelos Wiretaps Reveal Greed, F-BombsAfter Curcio told Carl Bonomo, his boss and uncle, about the situation with Adam, the senator’s son was made a telemarketing “consultant” at a reduced salary of $36,000. He was required to call 100 doctors a week in order to try and drum up business for PRI. Prosecutors presented emails in court indicating that Adam only called three doctors per week, and none of his efforts ever led to a solid sales lead.On cross examination, Gage asked if Curcio knew if the senator was supposed to help PRI get legislation passed that would benefit the company in exchange for hiring Adam. Curcio said that he did not and didn’t ask his bosses why they hired him.Conniff questioned Curcio on the accuracy of his log and how Curcio himself got his job at PRI. He testified that Curcio’s mother had asked his uncle to land him a job supervising the sales staff despite his own lack of experience in the field.Tatiana Martins, one of the prosecutors trying the case, followed up and asked Curcio: “Is your mother an elected official?”Curcio replied: “No.”Martins asked: “Is she the senate majority leader?”Curcio replied: “No.”Martins asked: “Does she control legislation that effects PRI?”Curcio replied: “No.”The second witness to take the stand was Vanessa Tibbits, one of the FBI agents who monitored the Skelos wiretaps. She explained the process of getting approvals to “go up on a wire” as well as the strict protocols that include the listening room being locked and only accessible to the public corruption squad due to the sensitivity of investigations like this. She testified before the first Skelos wiretaps were played in open federal court.In one conversation, the elder Skelos was heard speaking with state Sen. Jack Martins (R-Mineola) about making a joint statement announcing their intention to focus on water issues on Long Island. They discussed how they didn’t want to fund water-quality improvement projects supported by Nassau County Executive Ed Mangano and Suffolk County Executive Steve Bellone, but instead they wanted to do their own water projects. Skelos liked the idea of appeasing “the environmental nuts.”In another call, Adam whined to his father about Gov. Andrew Cuomo’s banning fracking. That’s because AbTech, the storm-water filtration firm the men are accused of coercing fees from, also makes fracking waste-water filters.“Arghhhh, this day sucks!” Adam is heard telling his dad in the wiretap.“It does,” his dad replies, “but we’re totally gonna focus on the other thing now.”Adam then urged his father to run for governor and unseat Cuomo.“I would be so proud if you would just kick his ass,” Adam said.The Republican state senator had choice words for the Democratic governor.“No more buddy-buddy,” Skelos said. “He’s full of shit.”
The Taylor Swift, Scooter Braun, Justin Bieber row explained- Advertisement – – Advertisement –
GLEN Mills, coach of the two fastest men in history – Usain Bolt and Yohan Blake – said he is not entirely in agreement with recent suggestions that track and field’s governing body, the IAAF, closes the book on existing world records and start anew.The most recent suggestion came from Gianni Merlo, president of the International Press Association, who suggested that such a move would help the sport improve its image, tarnished by recent incidents of doping, most notably the recent scandal involving the reported widespread institutionalized doping of athletes uncovered in Russia.There have also been incidents involving a number of African athletes who last year were arrested at a hotel in Spain in June 2016.“If the fight against doping has come to this point, if it is as difficult as we all agree it is, then I think that the moment has arrived to close the world record books in athletics and open new ones,” Merlo said in an open letter to IAAF President Sebastian Coe.However, Mills, who has coached Usain Bolt to world records in the 100m (9.58) and 200m (19.19), believes that wiping the slate clean would be a disservice to athletes who are completing clean.“It is a suggestion that has some merit but in the interest of balance, one is assuming that all records that are there are tainted and I do not believe so,” said the man who has steered Bolt to a historic three consecutive Olympic 100m and 200m titles.“How do you address the injustice that would be done to those who worked hard to achieve excellence?”Mills was not alone in his stance against Merlo’s suggestion.Former Olympic high jump champion Stefka Kostadinova has also hit out as the proposal.The 51-year-old Kostadinova, who is still the world record holder with a jump of 2.09 metres from the 1987 world championships in Rome, said the suggestion of expunging all existing records would be “unfair to all (athletes) who absolutely honestly reached the peak of their careers. (Sportsmax).